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Article

ALS-associated TBK1 variant p.G175S is defective in phosphorylation of p62 and impacts TBK1-mediated signalling and TDP-43 autophagic degradation.

Molecular and cellular neurosciences - 1 Oct 2020

Foster A D, Downing P, Figredo E, Polain N, Stott A, Layfield R, Rea S L

Abstract excerpt

Mutations affecting SQSTM1 coding for p62 and TANK-Binding Kinase 1 (TBK1) have been implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). TBK1 is a serine-threonine kinase that regulates p62's activity as an autophagy receptor via phosphorylation and also has roles in neuroinflammatory signalling pathways. The mechanisms underlying ALS and FTLD pathogenesis as a result...

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PMID: 32835772
DOI: 10.1016/j.mcn.2020.103539

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