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Article

Effects of ALS-associated TANK binding kinase 1 mutations on protein–protein interactions and kinase activity

20 Nov 2019

Abstract excerpt

gene associate with both sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we examine functional defects in 25 missense TBK1 mutations, focusing on kinase activity and protein-protein interactions. We identified kinase domain (KD) mutations that abolish kinase activity or display substrate-specific defects in specific pathways, such as innate immunity and autophagy. By contrast, mutations in the...

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PMID: 31748271
DOI: 10.1073/pnas.1915732116

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