Article

Machine Learning–Driven Antigen Selection Reveals Conserved T-Cell Targets for Broad Coronavirus Vaccination

2026-04-03

Abstract excerpt

<h4>Background</h4> Coronavirus outbreaks remain a persistent threat to global health, and vaccines based primarily on spike-specific immune responses are susceptible to antigenic variation. T-cell immunity directed against conserved internal viral proteins may provide a complementary and more variant-tolerant strategy for next-generation coronavirus vaccines. <h4>Methods</h4> We combined machine learning–guided...

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Literature Corpus work: e3882500-6e17-52dd-ac35-bdd701de2d3b
DOI: 10.64898/2026.04.02.716054

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