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Study protocol and statistical analysis plan for a randomized controlled trial evaluating the safety and feasibility of the recombinant human platelet-derived growth factor B (rhPDGF-BB)-enhanced collagen plug for complex perianal fistula healing

2026-06-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> A drug-repurposing-specific phenome-wide association study (PheWAS) demonstrated that patients with a single nucleotide variant that decreases expression of platelet-derived growth factor receptor beta (PDGFRβ) have a higher prevalence of fistulas, suggesting that PDGFRβ signaling is important for tissue repair. Recombinant human platelet derived growth factor B (rhPDGF) is...

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Literature Corpus work
e3500ae0-db21-581d-9465-b2e9fd2fb8b7
DOI
10.64898/2026.06.22.26356267
Open publication

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Study protocol and statistical analysis plan for a randomized controlled trial evaluating the safety and feasibility of the recombinant human platelet-derived growth factor B (rhPDGF-BB)-enhanced collagen plug for complex perianal fistula healingDOI 10.64898/2026.06.22.26356267
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