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Article

Exploring the relationship between anal fistula and colorectal cancer based on Mendelian randomization and bioinformatics.

Journal of cellular and molecular medicine - 1 Aug 2024

Liu Yicheng, Zhao Wenjun, Hu Weiye, Xu Jin, Zhang Haiyan, Huang Ting, Wu Chuang, Yang Jiajia, Mao Wenjing, Yao Xiaobing, Lu Yafeng, Wang Qingming

Abstract excerpt

The association between anal fistula patients and colorectal cancer, as well as the potential pathophysiological mechanisms, remains unclear. To explore the relationship between anal fistula and colorectal cancer and its potential mechanisms. Analysis of GEO and TCGA databases. Disease-related genes were also referenced from Coremine Medical, GeneCard and OMIM. Core hub genes were identified through...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39120548
DOI: 10.1111/jcmm.18537
PMCID: PMC11312262

Genes

BARX1
CALB2
CDKN2A
HOXD13
ITGB3
MID2
MMP1
PDGFRA
SIX2
TIMP1
TMEM121B
WNT10B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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