Article

Study protocol and statistical analysis plan for a randomized, double-blind, controlled trial evaluating recombinant human platelet-derived growth factor B (rhPDGF) in the reconstruction of complex head or neck defects following skin cancer excision

2026-05-04

Abstract excerpt

<h4>Background</h4> Phenome-wide association studies (PheWAS) can reveal novel associations between variants in drug-target genes and disease and, as such, can be used to predict new drug-indication pairs for repurposing drugs with a known mechanism of action. A platelet-derived growth factor receptor beta (PDGFRβ) PheWAS demonstrated that patients with a single nucleotide variant that reduces PDGFRβ expression e...

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Literature Corpus work: d0ce428a-c9e8-544d-9cac-565de9e8fbc6
DOI: 10.64898/2026.05.01.26352276

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