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Article

On the statistical properties of family-based association tests in datasets containing both pedigrees and unrelated case-control samples.

European journal of human genetics : EJHG - 1 Feb 2012

Hiekkalinna Tero, Göring Harald H H, Lambert Brian, Weiss Kenneth M, Norrgrann Petri, Schäffer Alejandro A, Terwilliger Joseph D

Abstract excerpt

A common approach to genetic mapping of loci for complex diseases is to perform a genome-wide association study (GWAS) by analyzing a vast number of SNP markers in cohorts of unrelated cases and controls. A direct motivation for the case-control design is that unrelated, affected individuals can be easier to collect than large families with multiple affected persons in the Western world. Despite its higher...

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Identifiers

PMID: 21934707
DOI: 10.1038/ejhg.2011.173
PMCID: PMC3260916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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