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Human Three-Dimensional Endometrial Epithelial Cell Model To Study Host Interactions with Vaginal Bacteria and Neisseria gonorrhoeae.

Infection and immunity - 1 Mar 2017

Łaniewski Paweł, Gomez Adriana, Hire Geoffrey, So Magdalene, Herbst-Kralovetz Melissa M

Abstract excerpt

Colonization of the endometrium by pathogenic bacteria ascending from the lower female reproductive tract (FRT) is associated with many gynecologic and obstetric health complications. To study these host-microbe interactions in vitro, we developed a human three-dimensional (3-D) endometrial epithelial cell (EEC) model using the HEC-1A cell line and the rotating wall vessel (RWV) bioreactor technology. Our model,...

Topics

Cell Culture Techniques
Cell Line
Chemokines
Cytokines
Female
Gonorrhea
Host-Pathogen Interactions
Humans
In Vitro Techniques
Mucins
Mucous Membrane

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neisseria gonorrhoeae

Vagina

Source

Open in PubMed Open full text

Identifiers

PMID: 28052997
DOI: 10.1128/IAI.01049-16
PMCID: PMC5328489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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