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MODY Only Monogenic? A Narrative Review of the Novel Rare and Low-Penetrant Variants.

International journal of molecular sciences - 13 Aug 2024

Hasballa Iderina, Maggi Davide

Abstract excerpt

Maturity-onset diabetes of the young (MODY) represents the most frequent form of monogenic diabetes mellitus (DM), currently classified in 14 distinct subtypes according to single gene mutations involved in the differentiation and function of pancreatic β-cells. A significant proportion of MODY has unknown etiology, suggesting that the genetic landscape is still to be explored. Recently, novel potentially...

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Diabetes Mellitus, Type 2
Genetic Association Studies
Genetic Predisposition to Disease
Homeodomain Proteins
Insulin-Secreting Cells

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Nuclear Proteins

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PMID: 39201476
DOI: 10.3390/ijms25168790
PMCID: PMC11354648

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MODY Only Monogenic? A Narrative Review of the Novel Rare and Low-Penetrant Variants.PMID 39201476Read ↗

Moody Only Monogenic? A Narrative Review of the Rare and Low-Penetrant Genetic VariantsSemantic proximity Read ↗

The Importance of Molecular Genetic Testing for Precision Diagnostics, Management, and Genetic Counseling in MODY Patients.Semantic proximity Read ↗

Targeted sequencing identifies novel variants in common and rare MODY genesSemantic proximity Read ↗

Rare Variants in NEUROD1 and PDX1 Are Low-Penetrance Causes of MODY, Whereas Those in APPL1 and WFS1 Are Not Associated With MODYSemantic proximity Read ↗

Novel insights into genetics and clinics of the HNF1A-MODYSemantic proximity Read ↗

MODY is prevalent in later-onset diabetes, has potential for targeted therapy but is challenging to identifySemantic proximity Read ↗

Comprehensive genomic analysis identifies pathogenic variants in maturity-onset diabetes of the young (MODY) patients in South India.Semantic proximity Read ↗

[MODY type diabetes: overview and recent findings].Semantic proximity Read ↗

Monogenic Childhood Diabetes: Dissecting Clinical Heterogeneity by Next-Generation Sequencing in Maturity-Onset Diabetes of the Young.Semantic proximity Read ↗

Diverse and rare candidate MODY gene variants were identified in one-fifth of a Bangladeshi cohort with nonobese, nonautoimmune youth-onset diabetes.Semantic proximity Read ↗

Genetic Variants and Therapeutic Approaches in Maturity-Onset Diabetes of the Young: A Retrospective AnalysisSemantic proximity Read ↗

Genetics and Pathophysiology of Maturity-onset Diabetes of the Young (MODY): A Review of Current TrendsSemantic proximity Read ↗

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