Back to search

Article

Fluoxetine pharmacokinetics and tissue distribution quantitatively supports a therapeutic role in COVID-19 at a minimum dose of 20 mg per day

2022-10-13

Abstract excerpt

<h4>Background: </h4>  Various in vitro studies have shown fluoxetine inhibits multiple variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen causing the coronavirus disease 2019 (COVID-19) worldwide pandemic and multiple observational clinical studies have shown that patients receiving fluoxetine experienced clinical benefit by lowering the risk of intubation and death. The aim of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e1ee826a-114d-50a1-9f5c-fe1d090ad0f9
DOI
10.12688/f1000research.53275.3
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Fluoxetine pharmacokinetics and tissue distribution quantitatively supports a therapeutic role in COVID-19 at a minimum dose of 20 mg per dayDOI 10.12688/f1000research.53275.3
Application of Physiologically Based Pharmacokinetic Modeling to Optimize Assessment of Age-Related Fluoxetine Accumulation in the Elderly.Semantic proximity
The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2Semantic proximity
Pharmacokinetic /Pharmacodynamic Considerations of Alternate Dosing Strategies of Tocilizumab in COVID-19Semantic proximity
Dose-dependent effects of the 3435 C>T genotype of ABCB1 gene on the steady-state plasma concentration of fluvoxamine in psychiatric patients.Semantic proximity
The relationship between serotonin transporter occupancy and extracellular serotonin concentration is hyperbolic, not linear: implications for safely tapering antidepressantsSemantic proximity
Effect of fluoxetine on pharmacokinetics of ritonavir.Semantic proximity
Examination of Medication Use Patterns by Age Group, Comorbidity, and Month in COVID-19 Positive Patients in a Large State-wide Health System During the Pandemic in 2020Semantic proximity
A Quantitative Systems Pharmacology Model of the Pathophysiology and Treatment of COVID-19 Predicts Optimal Timing of Pharmacological InterventionsSemantic proximity
Select a neighboring publication to make it the new centre.