Article
Effect of fluoxetine on pharmacokinetics of ritonavir.
Antimicrobial agents and chemotherapy - 1 Dec 1998
Ouellet D, Hsu A, Qian J, Lamm J E, Cavanaugh J H, Leonard J M, Granneman G R
Abstract excerpt
The potential interaction between fluoxetine, a known inhibitor of cytochrome P-450 isoform 2D6 (CYP2D6), and ritonavir, a human immunodeficiency virus type 1 protease inhibitor, was evaluated in this open-label study. Sixteen male and female subjects ranging in age from 18 to 40 years completed the study. Subjects received single doses of 600 mg of ritonavir on days 1 and 10. On study days 3 to 10, all subjects...
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