Article
Effect of fluoxetine on pharmacokinetics of ritonavir.
Antimicrobial agents and chemotherapy - 1 Dec 1998
Ouellet D, Hsu A, Qian J, Lamm J E, Cavanaugh J H, Leonard J M, Granneman G R
Abstract excerpt
The potential interaction between fluoxetine, a known inhibitor of cytochrome P-450 isoform 2D6 (CYP2D6), and ritonavir, a human immunodeficiency virus type 1 protease inhibitor, was evaluated in this open-label study. Sixteen male and female subjects ranging in age from 18 to 40 years completed...
Topics
- Adolescent
- Adult
- Anti-HIV Agents
- Antidepressive Agents, Second-Generation
- Area Under Curve
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 CYP2D6 Inhibitors
- Drug Interactions
- Enzyme Inhibitors
- Female
- Fluoxetine
- Genotype
- HIV Protease Inhibitors
- HIV-1
- Half-Life
- Humans
- Male
- Middle Aged