Article

Ixodes scapularis STING promotes Powassan virus infection in ticks

2026-01-28

Abstract excerpt

<title>Abstract</title> <p>The stimulator of interferon genes (STING) is a central adaptor in antiviral signaling, but its role in vectors that transmit human and animal pathogens remains poorly understood. Here, we show that the tick STING homolog, tSTING, facilitates Powassan virus (POWV) infection in Ixodes scapularis -- in contrast to the canonical antiviral activity of mammalian STING. Transcriptomic and fun...

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Literature Corpus work: e1d80c14-c2a5-5cc2-969e-8cf44617c085
DOI: 10.21203/rs.3.rs-8620180/v1

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