Article

Modeling Disease Evolution with Multilevel Selection: HIV as a Quasispecies Social Genome

2012-01-01

Abstract excerpt

Abstract How genetically simple pathogens like HIV overwhelm complex immune systems is not fully understood. One unexplored possibility is that epistatic interactions across genetically complementary quasispecies (i.e., group-level social heterosis) allow pathogens to escape immune suppression. We tested this hypothesis by simulating an “HIV-like” pathogen under simultaneous individual- and group-level selecti...

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Literature Corpus work: e17c2bc1-e75b-5ba2-9aee-061799f10ab8
DOI: 10.4303/jem/235553

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