Article

Safety and Efficacy Upon Infection in Sheep with Rift Valley Fever Virus ZH548-rA2, a Triple Mutant Rescued Virus

2023-12-21

Abstract excerpt

The introduction of three single nucleotide mutations into the genome of the virulent RVFV ZH548 strain allows the rescue of a fully attenuated virus in mice (ZH548-rA2). These mutations are located in the viral genes encoding the RdRp and the non-structural protein NSs. This paper shows the results obtained after subcutaneous inoculation of ZH548-rA2 in adult sheep and subsequent challenge with the parental virus...

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Identifiers and source

Literature Corpus work: a77cd977-8fe9-5e34-9be0-064b0a4fc262
DOI: 10.20944/preprints202312.1602.v1

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