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The Influence of Codon Optimization on the Immune Response and Protective Efficacy of DNA Vaccines based on the Dengue Envelope and NS1 Proteins

2023-11-15

Abstract excerpt

Dengue is a pan-tropical arthropod-borne disease, endemic in over 100 countries. The dengue virus comprises four antigenic serotypes (DENV 1-4). The envelope (E) and non-structural 1 (NS1) proteins are highly immunogenic, and the E protein carries epitopes eliciting neutralizing antibodies. In previous studies, mice immunizations with two DNA vaccines encoding the E ectodomain (pE1D2) and NS1 proteins (pcTPANS1) f...

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Literature Corpus work
e10c2a1a-25cc-5dac-ac0a-3e2908669eec
DOI
10.20944/preprints202311.1032.v1
Open publication

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