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T Cell Responses Induced by DNA Vaccines Based on the DENV2 E and NS1 Proteins in Mice: Importance in Protection and Immunodominant Epitope Identification

3 Jul 2019

Abstract excerpt

The importance of the cellular immune response against DENV has been increasingly highlighted in the past few years, in particular for vaccine development. We have previously constructed two plasmids, pE1D2 and pcTPANS1, encoding the envelope (E) ectodomain (domains I, II and III) and the non-structural 1 (NS1) protein of dengue virus serotype 2 (DENV2), respectively. In the present work, we analyzed the...

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PMID: 31333657
DOI: 10.3389/fimmu.2019.01522

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