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Induction of a Protective Response in Mice by the Dengue Virus NS3 Protein Using DNA Vaccines

21 Oct 2011

Abstract excerpt

The dengue non-structural 3 (NS3) is a multifunctional protein, containing a serino-protease domain, located at the N-terminal portion, and helicase, NTPase and RTPase domains present in the C-terminal region. This protein is considered the main target for CD4+ and CD8+ T cell responses during dengue infection, which may be involved in protection. However, few studies have been undertaken evaluating the use of...

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PMID: 22031819
DOI: 10.1371/journal.pone.0025685

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