Article
<i>De novo</i> steroidogenesis maintains female-specific Th2 identity and constrains effector function
2026-05-15
Abstract excerpt
<h4>ABSTRACT</h4> <h4>Background</h4> T helper 2 (Th2) lymphocytes orchestrate type-2 immunity and drive allergic diseases that disproportionately affect females. Sexual dimorphism in Th2 responses is well-documented, yet current models attribute sex differences exclusively to circulating gonadal hormones and sex chromosomes. Whether cell-intrinsic steroidogenesis, mediated by the enzyme Cyp11a1, contributes to...
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Identifiers and source
- Literature Corpus work
- e0f90e40-f467-5226-895a-2903da8fddcc
- DOI
- 10.64898/2026.05.13.724806