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Concordance Validation of GenomeGuard, a Lightweight VCF-Based Pharmacogenomic Interpretation Engine, Against PharmCAT Using 1000 Genomes South Asian Whole-Genome Sequencing Data

2026-06-29

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : Pharmacogenomic (PGx) testing holds transformative potential for precision medicine in South Asian populations, where clinically actionable allele frequencies diverge substantially from European-centric reference panels. However, existing PGx interpretation tools are computationally heavy and often require Dockerized Java environments, limiting point-of-care...

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Literature Corpus work: e0e6b66b-891d-5ef4-8eb5-9da980960017
DOI: 10.21203/rs.3.rs-10164850/v1

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