PHARMWATCH: A Multilayer Pharmacogenomics Safety System for Accurate Star Allele Interpretation

Abstract excerpt

The Clinical Pharmacogenetics Implementation Consortium (CPIC) bases its drug–gene recommendations on the assignment of star alleles, which map known genotypes to defined functional categories and corresponding drug dosage guidelines. The star allele framework, first proposed in 1996 for the CYP gene family and later formalized with CPIC’s establishment in 2010 [1, 2], remains foundational to pharmacogenomics. Ho...

Topics

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• Algorithms
• Alleles
• Cytochrome P-450 CYP2D6
• Genotyping Techniques
• Haplotypes
• High-Throughput Nucleotide Sequencing
• Pharmacogenetics
• Whole Genome Sequencing

Identifiers and source

Literature Corpus work

c52caf3d-e90d-5991-aa07-e2c72a8a67ed

DOI

10.64898/2026.02.26.26347200