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Article

CircCOPA promotes hepatocellular carcinoma progression through the HNRNPD/SPRED2 axis-mediated activation of ERK/MAPK signaling pathway

2026-04-21

Abstract excerpt

<title>Abstract</title> <p>CircRNAs are critically involved in the progression of numerous cancers, including hepatocellular carcinoma (HCC). While circCOPA has been reported to function as a tumor suppressor in glioblastoma, its role and underlying mechanisms in HCC remain largely unexplored. By analyzing the Gene Expression Omnibus (GEO), we identified a new oncogenic circRNA, hsa_circ_0008661 (circCOPA), which...

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Literature Corpus work
d88955cf-45f4-5343-9593-2e907cdb8032
DOI
10.21203/rs.3.rs-9321668/v1
Open publication

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