Back to search

Article

DSG2 Expression Defines a Stromal-Immune Organizational State in Head and Neck Squamous Cell Carcinoma

2026-06-25

Abstract excerpt

<h4>Background: </h4> /Objectives: Immune exclusion in head and neck squamous cell carcinoma (HNSCC) limits immunotherapy efficacy, yet the molecular determinants of stromal- immune organization remain incompletely characterized. The desmosomal cadherin DSG2 is highly expressed in squamous epithelium; its role in shaping the tumor microenvironment (TME) is unknown. <h4>Methods:</h4> We integrated bulk RNA-seq from...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e096ee7a-65d6-53fd-a09c-6c20b44300e8
DOI
10.20944/preprints202606.1850.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
DSG2 Expression Defines a Stromal-Immune Organizational State in Head and Neck Squamous Cell CarcinomaDOI 10.20944/preprints202606.1850.v1
Collagen remodeling promotes a GPCR-mediated mechanosensory immune checkpoint in ADGRG1+ CD8+ T cells and serves as a spatial biomarker of response to immunotherapySemantic proximity
Single‐cell sequencing of head and neck carcinoma: Transcriptional landscape and prognostic model based on malignant epithelial cell featuresSemantic proximity
Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencingSemantic proximity
Multi-omics characterization of cellular state diversity and bidirectional tumor-stroma/immune interactions in cervical squamous cell carcinomaSemantic proximity
Integrative Single-Cell and Bulk Transcriptomes Analyses Identify Intrinsic HNSCC Subtypes with Distinct Prognoses and Therapeutic VulnerabilitiesSemantic proximity
Immune Heterogeneity and Intercellular Networks of HPV-Related Head and Neck Squamous Cell Carcinoma at Single Cell ResolutionSemantic proximity
Constructing heterogeneous single-cell landscape and identifying microenvironment molecular characteristics of primary and lymphatic metastatic head and neck squamous cell carcinomaSemantic proximity
A highly resolved integrated single-cell atlas of HPV-negative head and neck cancerSemantic proximity
Single-cell RNA sequencing reveals pro-invasive cancer-associated fibroblasts in hypopharyngeal squamous cell carcinomaSemantic proximity
Multi-omic profiling identifies malignant subpopulations and a hypoxia-driven angiogenic axis as therapeutic vulnerabilities in sinonasal squamous cell carcinomaSemantic proximity
Germinal center B-cell subgroups in the tumor microenvironment cannot be overlooked: their involvement in prognosis, immunotherapy response, and treatment resistance in head and neck squamous carcinomaSemantic proximity
Single-cell transcriptomic analyses reveal heterogeneity and key subsets associated with survival and response to PD-1 blockade in cervical squamous cell carcinomaSemantic proximity
Select a neighboring publication to make it the new centre.