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Article

R132H IDH1 sensitizes glioma to the antiproliferative and cytotoxic effects of BET inhibition.

Journal of cancer research and clinical oncology - 1 Sept 2022

Sears Thomas K, Woolard Kevin D

Abstract excerpt

INTRODUCTION: Mutations in isocitrate dehydrogenase 1/2 (IDHmut) identify a subset of gliomas that exhibit epigenetic dysregulation via aberrant DNA methylation. These tumors are ultimately fatal and lack effective therapeutic strategies. Considering the epigenetic dysregulation of IDHmut gliomas, we hypothesized that epigenetic-targeting drugs may yield therapeutic benefits in gliomas bearing IDHmut. One set of...

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Identifiers

PMID: 35467128
DOI: 10.1007/s00432-022-04018-w
PMCID: PMC9349147

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