Article

BET bromodomain inhibitor HMBA synergizes with MEK inhibition in treatment of malignant glioma

2020-01-02

Abstract excerpt

(1) <h4>Background</h4> BET bromodomain proteins regulate transcription by binding acetylated histones and attracting key factors for e.g. transcriptional elongation. BET inhibitors have been developed to block pathogenic processes such as cancer and inflammation. Despite having potent biological activities, BET inhibitors have still not made a breakthrough in clinical use for treating cancer. Multiple resistance...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 573a40c0-689e-5189-ab00-1538248ddd19
DOI: 10.1101/2020.01.01.891739

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

BET bromodomain inhibitor HMBA synergizes with MEK inhibition in treatment of malignant gliomaDOI 10.1101/2020.01.01.891739Read

BH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant gliomaSemantic proximity Read

Targeting BET Bromodomains in CancerSemantic proximity Read

BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cellsSemantic proximity Read

Bromodomain Inhibitor Review: Bromodomain and Extra-terminal Family Protein Inhibitors as a Potential New Therapy in Central Nervous System TumorsSemantic proximity Read

The novel BET inhibitor UM-002 reduces glioblastoma cell proliferation and invasionSemantic proximity Read

CPI203, a BET inhibitor, down-regulates a consistent set of DNA synthesis genes across a wide array of glioblastoma linesSemantic proximity Read

A novel dual epigenetic approach targeting BET proteins and HDACs in Group 3 (MYC-driven) MedulloblastomaSemantic proximity Read

Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of ProteinsSemantic proximity Read

Targeting BET bromodomain proteins in cancer: The example of lymphomasSemantic proximity Read

Bromodomain and Extraterminal Domain (BET) Protein Inhibition Hinders Glioblastoma Progression by Inducing Autophagy-Dependent DifferentiationSemantic proximity Read

Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergismsSemantic proximity Read

Limited antitumor activity of combined BET and MEK inhibition in neuroblastomaSemantic proximity Read