Article

SETD2 non genomic loss of function in advanced systemic mastocytosis is mediated by an Aurora kinase A/MDM2 axis and can be therapeutically targeted

2022-12-19

Abstract excerpt

<h4>Background: </h4> The SETD2 tumor suppressor gene encodes a histone methyltransferase that safeguards transcription fidelity and genomic integrity via trimethylation of histone H3 lysine 36 (H3K36Me3). SETD2 loss of function has been observed in solid and hematologic malignancies. We have recently reported that most patients with advanced systemic mastocytosis (AdvSM) and some with indolent or smoldering SM di...

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Literature Corpus work: e05a1363-6faa-50b3-b6ba-5311dda7136b
DOI: 10.21203/rs.3.rs-2381244/v1

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