Leveraging AI to Explore Structural Contexts of Post-Translational Modifications in Drug Binding

Abstract excerpt

Post-translational modifications (PTMs) play a crucial role in allowing cells to expand the functionality of their proteins and adaptively regulate their signaling pathways. Defects in PTMs have been linked to numerous developmental disorders and human diseases, including cancer, diabetes, heart, neurodegenerative and metabolic diseases. PTMs are important targets in drug discovery, as they can significantly influ...

Topics

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• Data Mining
• Databases, Protein
• Datasets as Topic
• Disease
• Molecular Sequence Annotation
• Protein Processing, Post-Translational
• Proteomics
• User-Computer Interface

Identifiers and source

Literature Corpus work

e03b1c73-38ff-5160-a15e-de7658a5cbc9

DOI

10.1101/2025.01.14.633078