Article

Reversal of an existing hearing loss in <i>Spns2</i> mutant mice

2023-05-03

Abstract excerpt

Hearing loss is highly heterogeneous but one common form involves a failure to maintain the local ionic environment of the sensory hair cells reflected in a reduced endocochlear potential. We used a genetic approach to ask if this type of pathology can be reversed, using the Spns2 tm1a mouse mutant known to show this defect. By activating Spns2 gene transcription at different ages after the onset of hearing loss...

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Literature Corpus work: dfd6f422-758c-5d28-9a25-07aea8c2a204
DOI: 10.1101/2023.05.02.539081

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