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Single-cell and spatial analyses revealed the co-location of cancer stem cells and SPP1+ macrophage in hypoxic region that determines the poor prognosis in hepatocellular carcinoma

2023-09-26

Abstract excerpt

In hepatocellular carcinoma (HCC), classical cancer stem cells (CSC) markers were shared by normal stem cells, targeting which may hinder hepatic regeneration and cause liver failure. Additionally, the spatial structure of CSC still remained elusive. To address these limitations, we undertook a comprehensive study combining single-cell data (81,508 cells from 45 samples) and spatial data (38,191 spots from eight s...

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Literature Corpus work
df4eabc0-0a1b-581a-b307-a267e85b17f3
DOI
10.21203/rs.3.rs-3316797/v1
Open publication

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Single-cell and spatial analyses revealed the co-location of cancer stem cells and SPP1+ macrophage in hypoxic region that determines the poor prognosis in hepatocellular carcinomaDOI 10.21203/rs.3.rs-3316797/v1
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