Article

State-Dependent Transcriptomic Collapse of the Brain’s Lactate and Ketone Thermodynamic Sensors in Schizophrenia

2026-07-01

Abstract excerpt

Metabolic psychiatry has recently achieved unprecedented clinical rescue in treatment-resistant Schizophrenia (SCZ) utilizing targeted ketogenic interventions. However, the field has operated without a defined genomic anchor, leaving the biophysical mechanism of these therapies largely unexplained. Here, we report the discovery of the definitive metabolic sensor array driving this pathology. By integrating high-re...

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Literature Corpus work: dec3a9d8-ec51-58cb-b4f9-527b93d88724
DOI: 10.64898/2026.06.26.734782

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State-Dependent Transcriptomic Collapse of the Brain’s Lactate and Ketone Thermodynamic Sensors in SchizophreniaDOI 10.64898/2026.06.26.734782Read

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