Article

Questioning the association of the <i>STMN2</i> dinucleotide repeat with ALS

2022-05-02

Abstract excerpt

Lowered expression of STMN2 is associated with TDP-43 pathology in amyotrophic lateral sclerosis (ALS). Recently, the number of dinucleotide CA repeats in an intron of the STMN2 gene was reported to be associated with increased risk for ALS. Here, we used a case-control cohort of whole genome sequencing (WGS) as well as WGS from populations in the gnomAD cohort to attempt to replicate this proposed association. We...

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Literature Corpus work: de9cf627-de4a-5cd1-826b-ebb0250e9d4e
DOI: 10.1101/2022.04.30.22273566

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