Article

Assessment of <i>ATXN2</i> Repeat Expansion Length and Risk of ALS: A Meta-Analysis

2026-01-13

Abstract excerpt

ATXN2 expansions of ≥33 CAG-repeats are associated with spinocerebellar ataxia type 2, while “intermediate” length expansions have been associated with amyotrophic lateral sclerosis (ALS). Yet, no consensus is established regarding the lengths that define a true association with ALS risk, with recent studies debating between a lower limit of ≥29 or ≥31 repeats. Here, we assessed the risk of ALS imparted by various...

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Literature Corpus work: 93885367-a616-5dd0-b77c-209306ff4fd8
DOI: 10.64898/2026.01.09.26343811

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