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Characterising the motif composition and allele length distribution of <i>ZFHX3</i> GGC repeat expansions in amyotrophic lateral sclerosis

2026-03-10

Abstract excerpt

<h4>Background and objectives</h4> A pathogenic GGC repeat expansion in the zinc finger homeobox 3 ( ZFHX3 ) gene, encoding a pure polyglycine tract, is the cause of spinocerebellar ataxia type 4 (SCA4). Intermediate expansions of other SCA loci contribute to the risk of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease involving the progressive loss of motor neurons. There is increasing awa...

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Literature Corpus work
4c3f6dde-ed6c-55d2-9698-28d1d73e62e7
DOI
10.64898/2026.03.09.26347973
Open publication

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Characterising the motif composition and allele length distribution of <i>ZFHX3</i> GGC repeat expansions in amyotrophic lateral sclerosisDOI 10.64898/2026.03.09.26347973
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