Article

Hepatic injury signals drive proteomic reprogramming of the mesenchymal stem cells secretome to counteract liver damage

2026-08-06

Abstract excerpt

<title>Abstract</title> <p> Paracetamol (APAP) overdose remains a leading cause of acute liver failure (ALF), a life-threatening condition with limited therapeutic options. The secretome of mesenchymal stem cells (MSCs) contain immunomodulatory and pro-regenerative factors that promote endogenous liver regeneration in ALF. <italic>In vivo</italic> , MSCs respond dynamically to injury microenvironments, adaptin...

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Literature Corpus work: de7d9a99-53b7-52a8-a871-b577ffb05ed0
DOI: 10.21203/rs.3.rs-10393497/v1

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