Article
A genome-wide CRISPR-Cas9 screen identifies TGN46 as a host determinant for H-1PV susceptibility in pancreatic adenocarcinoma
2026-03-09
Abstract excerpt
Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy with limited response to current therapeutic strategies. Oncolytic viruses such as the rat protoparvovirus H-1PV represent promising alternatives; however, their clinical development is hindered by an incomplete understanding of virus-host interactions that determine tumor susceptibility. Here, we conducted a genome-scale CRISPR-Cas9 knocko...
Topics
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- Animal Virus Infections Studies
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Virus-based gene therapy research
Identifiers and source
- Literature Corpus work
- de7b2e18-cff7-5bc3-b04f-6a42f323726a
- DOI
- 10.64898/2026.03.06.710102