Article

Achilles' Heel of SARS-CoV-2: Transcription Regulatory Sequence and Leader Sequence in 5’ Untranslated Region have Unique Evolutionary Patterns and are Vital for Virus Replication in Infected Human Cells

2020-09-25

Abstract excerpt

<h4>Background: </h4> SARS-CoV-2 has generated a life-treating pandemic and is the main challenge of this century. Some untranslated regions (UTRs) in SARS-CoV-2 genome, specifically leader sequence and transcription regulatory sequence (TRS) in 5’UTR, can be considered as Achilles' heel of virus. Leader sequence are found at the 5' ends of all encoded transcripts that highlights its importance. TRS can expl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de4cc906-8b3b-58de-a651-6f27c30f8865
DOI: 10.20944/preprints202009.0602.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Achilles' Heel of SARS-CoV-2: Transcription Regulatory Sequence and Leader Sequence in 5’ Untranslated Region have Unique Evolutionary Patterns and are Vital for Virus Replication in Infected Human CellsDOI 10.20944/preprints202009.0602.v1Read

A Transcription Regulatory Sequence in the 5′ Untranslated Region of SARS-CoV-2 Is Vital for Virus Replication with an Altered Evolutionary Pattern against Human Inhibitory MicroRNAsSemantic proximity Read

Conserved Genomic Terminals of SARS-CoV-2 as Co-evolving Functional Elements and Potential Therapeutic TargetsSemantic proximity Read

Global cataloguing of variations in untranslated regions of viral genome and prediction of key host RNA binding protein-microRNA interactions modulating genome stability in SARS-CoV2Semantic proximity Read

SARS-CoV-2 mutations altering regulatory properties: deciphering host’s and virus’s perspectivesSemantic proximity Read

Comprehensive in-vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanismsSemantic proximity Read

miRNAs in SARS-CoV 2: A Spoke in the Wheel of PathogenesisSemantic proximity Read

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infectionSemantic proximity Read

RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related virusesSemantic proximity Read

Epigenetic Regulator miRNA Pattern Differences Among SARS-CoV, SARS-CoV-2, and SARS-CoV-2 World-Wide Isolates Delineated the Mystery Behind the Epic Pathogenicity and Distinct Clinical Characteristics of Pandemic COVID-19Semantic proximity Read

SARS-CoV-2: from its discovery to genome structure, transcription, and replicationSemantic proximity Read

Non-Coding RNAs and SARS-Related Coronaviruses.Semantic proximity Read

The highly conserved stem-loop II motif is dispensable for SARS-CoV-2Semantic proximity Read