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Maternal aspartame exposure alters lung Th1/Th2 cytokine balance in offspring through nuclear factor-κB activation

12 Dec 2024

Abstract excerpt

BACKGROUND: Epidemiological evidence suggests that maternal intake of nonnutritive sweeteners is positively associated with early childhood asthma incidence. We investigated the effects of maternal aspartame exposure during pregnancy and lactation on lung Th1/Th2 cytokine balance and intestinal microbiota in offspring and explored the mechanisms that mediate these effects. METHOD: Pregnant BALB/c mice were...

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PMID: 39672024
DOI: 10.1016/j.intimp.2024.113800

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