Article

Bi-phasic regulation of AIMP2 and its splice variant in PARP-1-dependent neurodegeneration

2022-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Parthanatos is a significant molecular cause of Parkinson’s disease, in which AIMP2 aberrantly activates PARP-1 through a physical interaction. Interestingly, AIMP2 has an antagonistic splice variant, named DX2, which compromises AIMP2-induced apoptosis via p53 or inflammatory pathway. Here we suggested that DX2 binds to PARP-1 with a higher affinity than AIMP2, deactivating it and improving syn...

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Literature Corpus work: dd7cd875-5756-5b8f-81da-0143d35330b4
DOI: 10.1101/2022.04.06.487280

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