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Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

4 Nov 2020

Abstract excerpt

The cell entry of SARS-CoV-2 has emerged as an attractive drug repurposing target for COVID-19. Here we combine genetics and chemical perturbation to demonstrate that ACE2-mediated entry of SARS-Cov and CoV-2 requires the cell surface heparan sulfate (HS) as an assisting cofactor: ablation of genes involved in HS biosynthesis or incubating cells with a HS mimetic both inhibit Spike-mediated viral entry. We show...

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PMID: 33298900
DOI: 10.1038/s41421-020-00222-5

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