Article

Glucocorticoid receptor activation induces gene-specific transcriptional memory and universally reversible changes in chromatin accessibility

2021-01-06

Abstract excerpt

Glucocorticoids are stress hormones that elicit cellular responses by binding to the glucocorticoid receptor (GR), a ligand-activated transcription factor. The exposure of cells to this hormone induces wide-spread changes in the chromatin landscape and gene expression. Previous studies have suggested that some of these changes are reversible whereas others persist even when the hormone is no longer around. However...

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Literature Corpus work: dd525594-e991-59c1-a8bb-41e797195e8a
DOI: 10.1101/2021.01.05.425406

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