Article

Clinical interpretation of integrative molecular profiles to guide precision cancer medicine

2020-09-23

Abstract excerpt

<h4>ABSTRACT</h4> Individual tumor molecular profiling is routinely used to detect single gene-variant (“first-order”) genomic alterations that may inform therapeutic actions -- for instance, a tumor with a BRAF p.V600E variant might be considered for RAF/MEK inhibitor therapy. Interactions between such first-order events (e.g., somatic-germline) and global molecular features (e.g. mutational signatures) are inc...

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Literature Corpus work: 295f1754-ec7c-5bca-ad0f-ac330286ae5b
DOI: 10.1101/2020.09.22.308833

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