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Article

Characterization of Newly Established Pralatrexate-resistant Cell Lines and the Mechanisms of Resistance

2020-09-08

Abstract excerpt

<title>Abstract</title> <p>Background Pralatrexate (PDX) is a novel antifolate approved for the treatment of patients with relapsed/refractory peripheral T-cell lymphoma. However, some patients exhibit intrinsic resistance or develop acquired resistance to PDX. Here, we evaluated the mechanisms underlying acquired drug resistance and identified strategies to prevent resistance. Methods We established two PDX-re...

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Literature Corpus work
dce11dbf-8713-5ab7-aef9-1a6836a72965
DOI
10.21203/rs.3.rs-46923/v1
Open publication

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Characterization of Newly Established Pralatrexate-resistant Cell Lines and the Mechanisms of ResistanceDOI 10.21203/rs.3.rs-46923/v1
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