Article

Multi-organ AI Endophenotypes Chart the Heterogeneity of Pan-disease in the Brain, Eye, and Heart

2025-08-13

Abstract excerpt

Disease heterogeneity and commonality pose significant challenges to precision medicine, as traditional approaches frequently focus on single disease entities and overlook shared mechanisms across conditions 1 . Inspired by pan-cancer 2 and multi-organ research 3 , we introduce the concept of “pan-disease” to investigate the heterogeneity and shared etiology in brain, eye, and heart diseases. Leveraging individual...

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Literature Corpus work: dc66fa44-71ba-5340-ac8a-90dbfbfe24d2
DOI: 10.1101/2025.08.09.25333350

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