Article
Multi-omic analysis of deep learning-derived phenotypes links ophthalmic imaging to cardiovascular and neurological traits.
Nature cardiovascular research - 1 Jun 2026
Julian Thomas H, Dou Haoran, Duan Jinming, Huang Jinghan, Yoo Esther, Green David J, Strange Andrew, Alhathli Elham, Sperrin Matthew, Keane Pearse A, Chew Emily Y, Keavney Bernard, Fitzgerald Tomas W, Cooper-Knock Johnathan, Birney Ewan, Frangi Alejandro F, Sergouniotis Panagiotis I
Abstract excerpt
The eye is a recognized source of biomarkers for cardiovascular and neurodegenerative disease risk. Here we characterize the breadth of these associations and identify biological axes that may mediate them. Using UK Biobank data, we developed a multi-omic analysis pipeline integrating physiological, radiomic, metabolomic and genomic information. We trained retinal adversarial autoencoders to represent optical...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.