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Article

Brain-heart-eye axis revealed by multi-organ imaging genetics and proteomics.

Nature biomedical engineering - 1 Jun 2026

Boquet-Pujadas Aleix, Anagnostakis Filippos, Duggan Michael R, Joynes Cassandra M, Toga Arthur W, Yang Zhijian, Walker Keenan A, Davatzikos Christos, Wen Junhao

Abstract excerpt

Multi-organ research investigates interconnections among multiple human organ systems, enhancing our understanding of human aging and disease mechanisms. Here we use multi-organ imaging, individual- and summary-level genetics, and proteomics data consolidated via the MULTI Consortium to delineate a brain-heart-eye axis using brain patterns of structural covariance (PSCs), heart imaging-derived phenotypes (IDPs)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41028329
DOI: 10.1038/s41551-025-01506-5
PMCID: PMC13067127

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