Article

Frameshift Mutations in the Microevolution and Macroevolution of Viruses

2022-07-21

Abstract excerpt

<h4>ABSTRACT</h4> Some nucleotide insertions or deletions (indels) in open reading frames of virus genes lead to frameshift mutations (FSMs), which can drastically change amino acid sequences. Most FSMs are deleterious and inhibited by natural selection, but some FSMs could aid viruses in adapting to new hosts, escaping immunity, or changing viral pathogenicity or transmissibility. Surprisingly, various fundament...

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Literature Corpus work: dc1d7af4-da69-5136-9168-6876ad88f8fe
DOI: 10.1101/2022.07.20.500745

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