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Unveiling of Evolution Pattern for HY12 Enterovirus Quasispecies and Pathogenicity Alteration.

Viruses - 28 Oct 2021

Chang Xiaoran, Zhu Lisai, Hu Junying, Zhang Qun, Zhang Fuhui, Lin Qian, Gai Xiaochun, Wang Xinping

Abstract excerpt

Enterovirus, like the majority of RNA viruses, evolves to survive the changeable environments by a variety of strategies. Here, we showed that HY12 virus evolved to alter its characteristics and pathogenicity by employing a non-synonymous mutation. Analyses of 5'UTR, VP1 and VP2 gene sequences revealed the existence of HY12 virus in an array of mutants defined as quasispecies. The determination of diversity and...

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Identifiers

PMID: 34834980
DOI: 10.3390/v13112174
PMCID: PMC8619380

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