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Article

Limited protection against early-life cytomegalovirus infection results from deficiency of cytotoxic CD8 T cells

2024-07-16

Abstract excerpt

<h4>Summary</h4> Differential antiviral T cell immunity in early life impacts the clinical outcome of Cytomegalovirus (CMV) infection, but the underlying mechanisms are not well understood. Here, we found delayed enrichment of early-life murine CMV-specific CD8 T cells due to a general deficiency of αβ T cells. Adoptive transfer of naïve adult T cells into neonates did not protect due to a blockade of CD8 but not...

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Identifiers and source

Literature Corpus work
dc15ff16-c88b-50f9-8901-a758c9dcb038
DOI
10.1101/2024.07.10.602923
Open publication

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Limited protection against early-life cytomegalovirus infection results from deficiency of cytotoxic CD8 T cellsDOI 10.1101/2024.07.10.602923
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