Article
Mature CD8(+) T lymphocyte response to viral infection during fetal life.
The Journal of clinical investigation - 1 Jun 2003
Marchant Arnaud, Appay Victor, Van Der Sande Marianne, Dulphy Nicolas, Liesnard Corinne, Kidd Michael, Kaye Steve, Ojuola Olubukola, Gillespie Geraldine M A, Vargas Cuero Ana L, Cerundolo Vincenzo, Callan Margaret, McAdam Keith P W J, Rowland-Jones Sarah L, Donner Catherine, McMichael Andrew J, Whittle Hilton
Abstract excerpt
Immunization of newborns against viral infections may be hampered by ineffective CD8(+) T cell responses. To characterize the function of CD8(+) T lymphocytes in early life, we studied newborns with congenital human cytomegalovirus (HCMV) infection. We demonstrate that HCMV infection in utero leads to the expansion and the differentiation of mature HCMV-specific CD8(+) T cells, which have similar characteristics...
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