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Cytomegalovirus Infection in Gambian Infants Leads to Profound CD8 T-Cell Differentiation

22 Mar 2007

Abstract excerpt

Cytomegalovirus (CMV) infection is endemic in Gambian infants, with 62% infected by 3 months and 85% by 12 months of age. We studied the CD8 T-cell responses of infants to CMV following primary infection. CMV-specific CD8 T cells, identified with tetramers, showed a fully differentiated phenotype (CD28(-) CD62L(-) CD95(+) perforin(+) granzyme A(+) Bcl-2(low)). Strikingly, the overall CD8 T-cell population...

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PMID: 17376923
DOI: 10.1128/jvi.00052-07

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