Article

Leveraging a genetic proxy to investigate the effects of lifelong cardiac sodium channel blockade

2025-04-21

Abstract excerpt

Atrial fibrillation (AFib) and other cardiac arrhythmias pose a major public health burden but prevention remains difficult. Here, we investigated a genetic variant which we found to act like a natural lifelong cardiac sodium channel blockade. We studied the impact of the Finnish-enriched SCN5A missense variant (rs45620037 [T220I]) on cardiac arrhythmias, associated mortality and electrocardiographic (ECG) phenoty...

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Literature Corpus work: dc07dba8-3cc9-5dde-8273-cb6dcdd3acf3
DOI: 10.1101/2025.04.15.25325909

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